Description

Koumine CAS NO 1358-76-5 is a naturally occurring indole alkaloid, a key bioactive constituent isolated from the traditional medicinal plant *Gelsemium elegans*. This compound is of significant interest for its unique pharmacological profile and serves as a critical reference standard and research material. It is primarily sought after by researchers and developers in the pharmaceutical, biotechnology, and natural product sectors for investigating neuropharmacology and developing novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in drug discovery and development.
• Neuroscience Research: Serves as a crucial tool compound for studying its effects on neuronal receptors and ion channels, aiding in the exploration of mechanisms related to analgesia and neuro-modulation.
• Natural Product Isolation & Analysis: Employed as a benchmark in the isolation, purification, and quantitative analysis of alkaloids from plant extracts and traditional medicine preparations.
• Bioactivity Screening: Used in high-throughput screening (HTS) assays to evaluate biological activity and identify potential lead compounds for new drug candidates.
• Academic & Institutional Research: Essential for universities and research institutes conducting studies in phytochemistry, pharmacology, and toxicology.
• Chemical Synthesis Intermediate: Acts as a starting material or intermediate for the semi-synthesis of novel analogs with potentially enhanced or modified biological properties.

Basic Information

Product Name	Koumine
CAS No.	1358-76-5
Molecular Formula	C₂₀H₂₂N₂O₂
Molecular Weight	322.40 g/mol
Synonyms	Koumine; (4R,17R,18S,20S)-18-Ethyl-4,6,16,18,20-pentamethyl-14,15-didehydro-10,17-methano-10H,17H-4,6-ethenocyclopenta[3',4']cycloocta[1',2':3,4]cyclopenta[1,2-d]pyrido[3,4-b]indol-10-ol; Gelsemine, 11-methoxy-; 11-Methoxygelsemine
EINECS	Contact for details

Quality Control

Our Koumine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for research and reference standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and analytical data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.