Description

7,8-Dihydroneopterin is a key intermediate in the biosynthesis of tetrahydrobiopterin, an essential cofactor for aromatic amino acid hydroxylases and nitric oxide synthases. This compound is crucial for research and development in biochemistry, neurobiology, and metabolic studies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focusing on pterin metabolism and related disorders.

Application

• Biochemical Research: Critical intermediate for studying the biosynthesis and regulation of tetrahydrobiopterin (BH4).
• Pharmaceutical Development: Used in the research of therapeutic agents targeting neurotransmitter synthesis and nitric oxide pathways.
• Diagnostic Reagents: Serves as a reference standard or precursor in assays for inborn errors of metabolism, such as phenylketonuria (PKU).
• Enzymology Studies: Employed as a substrate or intermediate in enzymatic studies of GTP cyclohydrolase I and other enzymes in the pterin pathway.
• Cell Culture & Neuroscience: Used in research models to investigate the role of BH4 in neuronal function and protection.
• Reference Standard: High-purity material for analytical method development and quality control in related pharmaceutical products.

Basic Information

Product Name	7,8-Dihydroneopterin
CAS No.	1218-98-0
Molecular Formula	C9H13N5O4
Molecular Weight	255.23 g/mol
Synonyms	7,8-Dihydroneopterin; 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine; D-erythro-7,8-Dihydroneopterin; 6-(1,2,3-Trihydroxypropyl)-7,8-dihydro-2-amino-4(3H)-pteridinone; Neopterin, 7,8-dihydro-; D-erythro-Neopterin, 7,8-dihydro-
EINECS	214-941-6

Quality Control

Our 7,8-Dihydroneopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. The material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.