Description

n-Acetyl-5-Hydroxytryptamine is a key biochemical intermediate, specifically the acetylated derivative of serotonin. This compound matters for its role as a direct precursor in the biosynthesis of melatonin, making it a critical material for research and production in neurochemistry and endocrinology. It is primarily needed by manufacturers in the pharmaceutical, nutraceutical, and advanced life science research sectors for developing therapeutic agents and high-purity reference standards.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of melatonin and related neuroactive compounds.
• Biochemical Research: Used as a standard and reagent in studies of serotonin metabolism, sleep-wake cycles, and circadian rhythm biology.
• Nutraceutical Production: Employed in the manufacture of high-purity melatonin supplements and other dietary ingredients targeting sleep support.
• Reference Standard: Provides an essential certified reference material (CRM) for quality control and analytical method development in regulatory and QC laboratories.
• Enzymology Studies: Acts as a substrate for enzymes like serotonin N-acetyltransferase (SNAT) in kinetic and mechanistic investigations.

Basic Information

Product Name	n-Acetyl-5-Hydroxytryptamine
CAS No.	1210-83-9
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	N-Acetylserotonin; NAS; 5-Hydroxy-N-acetyltryptamine; 5-Hydroxytryptamine, N-acetyl-; N-Acetyl-5-HT; O-Demethylmelatonin; Melatonin Precursor; 3-(2-Acetamidoethyl)-5-hydroxyindole
EINECS	214-927-4

Quality Control

Our n-Acetyl-5-Hydroxytryptamine is manufactured under strict quality management systems. We offer material suitable for research and commercial use, with standard purity grades meeting or exceeding 98% (HPLC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every batch to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as argon or nitrogen to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.