Description

2-Deoxy-D-Glucose (CAS NO 154-17-6) is a synthetic glucose analog where the 2-hydroxyl group is replaced by hydrogen, a structural modification that grants it unique biochemical properties. This compound is a critical tool in metabolic research, primarily functioning as a competitive inhibitor of glycolysis and glucose metabolism. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity biochemicals for metabolic studies, cancer research, and antiviral drug development.

Application

• Metabolic Research & Glycolysis Inhibition: Used as a standard tool to study glucose uptake, hexokinase activity, and cellular energy metabolism in vitro and in vivo.
• Oncology & Cancer Research: Investigated for its potential to target the altered metabolic pathways (Warburg effect) in cancer cells, serving as a basis for developing therapeutic strategies.
• Virology & Antiviral Studies: Employed in research to explore its inhibitory effects on the replication of certain viruses by disrupting N-linked glycosylation and energy production in infected cells.
• Diagnostic Agent Development: Serves as a precursor or reference compound in the development of positron emission tomography (PET) tracers, such as [18F]FDG analogs, for imaging glucose metabolism.
• Biochemical Reagent & Reference Standard: Supplied as a high-purity analytical standard for quality control in pharmaceutical labs and as a key reagent in enzymatic assay kits.

Basic Information

Product Name	2-Deoxy-D-Glucose
CAS No.	154-17-6
Molecular Formula	C6H12O5
Molecular Weight	164.16 g/mol
Synonyms	2-Deoxy-D-glucose; 2-Deoxy-D-arabino-hexose; D-2-Deoxyglucose; 2-DG; 2-Deoxyglucose; D-Arabino-2-deoxyhexose; 2-Desoxy-D-glucose; NSC 15193; D-Glucose, 2-deoxy-
EINECS	205-823-0

Quality Control

Our 2-Deoxy-D-Glucose is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity. Standard quality parameters include identification by IR spectroscopy, assay by HPLC, and control of specific impurities. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with each shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Specific Optical Rotation	+40° to +50° (c=1 in H2O)
Loss on Drying	≤ 1.0 %
Residue on Ignition	≤ 0.1 %
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.