Description

Trimethobenzamide is a potent antiemetic agent belonging to the benzamide class of pharmaceuticals. Its primary value lies in its ability to effectively prevent and treat nausea and vomiting, making it a critical component in therapeutic regimens. This compound is essential for pharmaceutical manufacturers and research institutions developing formulations for postoperative care, chemotherapy-induced nausea, and other clinical conditions requiring antiemetic intervention.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of prescription antiemetic medications.
• Injectable Formulations: Used in parenteral solutions for rapid-onset control of severe nausea and vomiting in clinical settings.
• Oral Dosage Forms: Incorporated into capsules and tablets for outpatient management of nausea.
• Oncology Supportive Care: Mitigates nausea and vomiting associated with chemotherapy and radiation therapy.
• Postoperative Recovery: Administered to prevent and treat nausea following surgical procedures.
• Veterinary Medicine: Applied in veterinary pharmaceuticals for antiemetic purposes in animals.
• Biochemical Research: Serves as a reference standard and tool for studying dopaminergic and antiemetic pathways.
• Drug Intermediate: Used in the synthetic pathway for more complex pharmaceutical compounds.

Basic Information

Product Name	Trimethobenzamide
CAS No.	138-56-7
Molecular Formula	C21H28N2O5
Molecular Weight	388.46 g/mol
Synonyms	4-(2-(Dimethylamino)ethoxy)-N-((2,4,6-trimethoxyphenyl)methyl)benzamide; Tigan; Ticon; Benzamide, 4-[2-(dimethylamino)ethoxy]-N-[[(2,4,6-trimethoxyphenyl)methyl]carbamoyl]-; Ro 2-9578; Trimazide; Trimethobenzamide Hydrochloride (salt form); Antiemetic Benzamide
EINECS	205-332-7

Quality Control

Our Trimethobenzamide is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for pharmaceutical applications, with testing aligned with pharmacopeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to ensure traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Microbial Limits	Meets Ph. Eur./USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.