Description

3-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-4-Methyl-5-[4,6,6-Trihydroxy-4,6-Dioxo-3,5-Dioxa-4,6-Diphospha(V)Hexan-1-Yl]Thiazol-3-Ium is a high-purity, complex heterocyclic compound that serves as a critical intermediate in advanced organic synthesis. Its unique molecular structure, featuring fused pyrimidine and thiazole rings with a phosphoryl moiety, makes it a valuable building block for developing novel active pharmaceutical ingredients (APIs) and specialty fine chemicals. This compound is essential for research and production in the pharmaceutical, agrochemical, and life science sectors, where precise molecular architecture is required for target-specific activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and antibacterial agents, leveraging its complex heterocyclic core.
• Agrochemical Research: Used in developing next-generation herbicides and fungicides with targeted modes of action.
• Biochemical Probe Synthesis: Serves as a scaffold for creating labeled compounds and probes used in biochemical and pharmacological research.
• Ligand and Catalyst Development: The phosphoryl and nitrogen-rich structure makes it suitable for designing specialized ligands in coordination chemistry and catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic & Industrial R&D: A valuable reagent for exploring new chemical entities and reaction pathways in synthetic organic chemistry.

Basic Information

Product Name	3-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-4-Methyl-5-[4,6,6-Trihydroxy-4,6-Dioxo-3,5-Dioxa-4,6-Diphospha(V)Hexan-1-Yl]Thiazol-3-Ium
CAS No.	136-08-3
Molecular Formula	C14H20N5O8P2S
Molecular Weight	480.35 g/mol
Synonyms	Thiamine Pyrophosphate Chloride (TPP-Cl); Cocarboxylase Chloride; Vitamin B1 Pyrophosphate Ester Chloride; Thiamine Diphosphate Chloride; Aneurin Pyrophosphate; 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium Chloride Pyrophosphate Ester; ThPP Chloride
EINECS	205-225-0

Quality Control

Our 3-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-4-Methyl-5-[4,6,6-Trihydroxy-4,6-Dioxo-3,5-Dioxa-4,6-Diphospha(V)Hexan-1-Yl]Thiazol-3-Ium is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can compromise product stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.