Description

α-Lobeline Hydrochloride is a high-purity alkaloid salt derived from Lobelia inflata, known for its specific pharmacological activity. This compound is critical for research and development in neuroscience and respiratory pharmacology due to its action as a nicotinic receptor agonist. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of reference standards and diagnostic reagents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and method validation in drug manufacturing.
• Neuroscience Research: Employed in vitro and in vivo studies to investigate nicotinic acetylcholine receptor (nAChR) function and modulation.
• Respiratory Research: Applied in preclinical studies exploring respiratory stimulants and agents affecting the carotid body.
• Biochemical Assay Development: Serves as a key reagent in developing high-throughput screening assays for drug discovery.
• Academic & Clinical Research: Supports fundamental research into addiction, smoking cessation mechanisms, and cognitive function.

Basic Information

Product Name	α-Lobeline Hydrochloride
CAS No.	134-63-4
Molecular Formula	C22H27NO2 • HCl
Molecular Weight	373.92 g/mol
Synonyms	Lobeline Hydrochloride; (-)-Lobeline Hydrochloride; L-Lobeline Hydrochloride; α-Lobeline HCl; 2-[(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidyl]-1-phenylethanone Hydrochloride; Inflatine Hydrochloride; Lobelia Alkaloid Hydrochloride
EINECS	205-148-2

Quality Control

Our α-Lobeline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.