Description

1-β-D-Arabinofuranosyl-5-Fluoro-(1H,3H)-Pyrimidine-2,4-Dione is a key fluorinated nucleoside derivative, widely recognized as a critical intermediate in the synthesis of antiviral and anticancer pharmaceuticals. Its value lies in its precise chemical structure, which serves as a foundational building block for developing potent active pharmaceutical ingredients (APIs). This compound is essential for manufacturers and research institutions in the pharmaceutical and biotechnology sectors focused on nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a crucial building block in the synthesis of antiviral drugs, particularly those targeting viral polymerases.
• Oncology Research: Serves as a precursor in the development of chemotherapeutic agents and prodrugs designed for targeted cancer therapy.
• Antiviral Agent Development: Integral to the research and production of nucleoside analogues used to treat herpesviruses and other viral infections.
• Biochemical Research: Used as a standard or reagent in studies involving DNA/RNA synthesis inhibition, enzyme kinetics, and molecular biology.
• Process Chemistry: Employed in scale-up and optimization processes for the commercial manufacturing of fluorinated pyrimidine-based APIs.
• Contract Manufacturing (CMO/CDMO): Supplied to contract organizations for the production of clinical trial materials and commercial drug batches.

Basic Information

Product Name	1-β-D-Arabinofuranosyl-5-Fluoro-(1H,3H)-Pyrimidine-2,4-Dione
CAS No.	131-06-6
Molecular Formula	C9H11FN2O6
Molecular Weight	262.19 g/mol
Synonyms	5-Fluoro-2'-deoxyuridine; 5-Fluoro-2'-deoxyuridine (FdUrd); 5-Fluoro-2'-deoxyuridine; Floxuridine Impurity; 1-(2-Deoxy-β-D-ribofuranosyl)-5-fluorouracil; 5-Fluoro-1-(2-deoxy-β-D-ribofuranosyl)uracil; 5-Fluoro-2'-deoxyuridine (5-FUDR); 2'-Deoxy-5-fluorouridine
EINECS	205-027-1

Quality Control

Our 1-β-D-Arabinofuranosyl-5-Fluoro-(1H,3H)-Pyrimidine-2,4-Dione is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.