Description

α-Yohimbine is a selective α-2 adrenergic receptor antagonist derived from the bark of the *Pausinystalia yohimbe* tree. This compound is of significant commercial interest for its role as a key intermediate in the synthesis of pharmaceutical actives and for research into metabolic and neurological pathways. It is primarily sought by manufacturers in the pharmaceutical, nutraceutical, and research chemical sectors for product development and high-purity applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) targeting adrenergic systems.
• Dietary Supplement Formulation: Used as a principal component in weight management and performance-enhancing nutraceutical products.
• Biochemical Research: Employed in preclinical studies to investigate α-2 adrenergic receptor function and related physiological effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in laboratory settings.
• Cosmeceutical Applications: Incorporated into specialized formulations for its purported lipolytic (fat-reducing) properties.

Basic Information

Product Name	α-Yohimbine
CAS No.	131-03-3
Molecular Formula	C21H26N2O3
Molecular Weight	354.45 g/mol
Synonyms	Yohimbine; Corynine; Aphrodine; Quebrachine; 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester; (16α,17α)-17-Hydroxyyohimban-16-carboxylic acid methyl ester
EINECS	205-019-5

Quality Control

Our α-Yohimbine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We offer material suitable for research and commercial use, with specifications that can meet the requirements of various pharmacopoeial standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee supply chain transparency and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.