Description

Protopine CAS NO 130-86-9 is a benzylisoquinoline alkaloid of significant interest in pharmaceutical and biochemical research. This versatile compound serves as a key intermediate and reference standard due to its unique pharmacological profile and natural origin. It is primarily utilized by research institutions, pharmaceutical developers, and manufacturers of high-purity botanical extracts seeking consistent, high-quality bioactive ingredients.

Application

• Pharmaceutical Research & Development: As a reference standard and active pharmaceutical ingredient (API) intermediate for studying its effects on smooth muscle, cardiovascular function, and potential neurological applications.
• Natural Product & Botanical Extract Standardization: Used for the qualitative and quantitative analysis (HPLC, LC-MS) of protopine content in plant materials like *Corydalis* and *Fumaria* species.
• Biochemical Assays & Screening: Employed in in vitro studies to investigate its interactions with various enzymes and receptor systems, including its known acetylcholinesterase inhibitory activity.
• Academic & Clinical Research: Serves as a crucial reagent for pharmacological studies exploring its anti-inflammatory, analgesic, and potential anti-cancer properties.
• Analytical Chemistry: Functions as a high-purity calibrant and system suitability compound in chromatographic methods for alkaloid analysis.

Basic Information

Product Name	Protopine
CAS No.	130-86-9
Molecular Formula	C20H19NO5
Molecular Weight	353.37 g/mol
Synonyms	Fumarine; Macleyine; 4,6,7,14-Tetrahydro-5-methylbis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one; 5,6,13,13a-Tetradehydro-9,10-dimethoxy-6-methylberbin-8-one; Bicuculline intermediate; Corydalis alkaloid
EINECS	204-996-5

Quality Control

Our Protopine is produced and tested under a strict quality management system to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant guidelines for reference standards and can provide material suitable for use in regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.