Description

Senecionine is a pyrrolizidine alkaloid (PA) of significant interest in research and pharmaceutical development. This compound is primarily valued for its role as a reference standard and a key chemical entity in toxicological and metabolic studies. It is essential for laboratories and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors requiring high-purity phytochemicals for analytical and research purposes. Our supply of Senecionine CAS NO 130-01-8 ensures consistent quality and reliability for critical applications.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of pyrrolizidine alkaloids in drug substances and herbal products.
• Toxicology Research: Serves as a model compound for studying the hepatotoxic and genotoxic effects of pyrrolizidine alkaloids, crucial for safety assessments.
• Analytical Chemistry: Employed as an internal or external standard in advanced analytical techniques like HPLC, LC-MS, and GC-MS for method development and validation.
• Phytochemical & Natural Product Research: Used in the isolation, characterization, and study of bioactive compounds from Senecio and other plant species.
• Quality Control in Herbal Supplements: Critical for testing and ensuring the absence or safe limits of toxic pyrrolizidine alkaloids in consumer health products.
• Biochemical Pathway Studies: Utilized in metabolic studies to understand the biosynthesis and detoxification pathways of plant alkaloids.

Basic Information

Product Name	Senecionine
CAS No.	130-01-8
Molecular Formula	C18H25NO5
Molecular Weight	335.40 g/mol
Synonyms	Senecionine; 12,18-Didehydrosenecionan-11,16-dione; (13Z)-Senecion-11-en-3,5,8-triol; Integerrimine; Jacobine; Retrorsine; Senecionine alkaloid; NSC 169915; Pyrrolizidine alkaloid PA
EINECS	Contact for details

Quality Control

Our Senecionine is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.