Description

Azaserine is a potent diazo compound and a naturally occurring glutamine analog with significant biochemical activity. This product is valued for its role as a selective inhibitor of glutamine-utilizing enzymes, making it a crucial tool in biochemical and pharmacological research. It is primarily utilized by research institutions and pharmaceutical companies investigating metabolic pathways, enzyme mechanisms, and as a reference standard in analytical studies.

Application

• Biochemical Research: Used as a specific inhibitor of enzymes like glutamine amidotransferases and γ-glutamyl transpeptidase to study nitrogen metabolism and amino acid biosynthesis.
• Pharmacological Studies: Serves as a model compound in cancer research due to its historical relevance as an antitumor antibiotic and its ability to interfere with nucleotide synthesis.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, LC-MS, and NMR for method development, validation, and quality control in laboratory settings.
• Enzyme Kinetics: A key reagent for investigating the kinetics and inhibition profiles of glutamine-dependent enzymatic reactions in vitro.
• Microbiology Research: Used in studies exploring the biosynthesis of purines and pyrimidines in various microbial systems.

Basic Information

Product Name	Azaserine
CAS No.	115-02-6
Molecular Formula	C5H7N3O4
Molecular Weight	173.13 g/mol
Synonyms	O-Diazoacetyl-L-serine; L-Azaserine; Azaserine; Antibiotic 25; NSC 742; Diazoacetate serine; L-Serine, diazoacetate (ester); (S)-2-Amino-3-hydroxypropanoic acid 2-diazoacetate
EINECS	204-058-5

Quality Control

Our Azaserine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by IR and NMR, purity determination by HPLC, and verification of moisture content. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.