Description

Phosphocitrate is a potent, naturally occurring inhibitor of pathological calcification and crystal formation, offering a unique mechanism of action for research and development. Its significance lies in its ability to specifically target and disrupt the growth of hydroxyapatite and calcium oxalate crystals, which are central to numerous disease processes. This makes it a critical compound for researchers and formulators in the pharmaceutical, biomedical, and advanced materials sectors, particularly for investigating treatments for conditions like vascular calcification, kidney stones, and osteoarthritis.

Application

• Biomedical Research: A key tool for studying the mechanisms of pathological calcification in cardiovascular diseases, nephrolithiasis (kidney stones), and articular cartilage calcification.
• Pharmaceutical Development: Investigated as a potential active pharmaceutical ingredient (API) or lead compound for novel therapeutics targeting ectopic calcification disorders.
• In Vitro Diagnostics: Used in assay development and calibration for tests measuring calcification inhibitors or crystal growth kinetics.
• Dental Research: Studied for its effects on dental calculus (tartar) formation and enamel demineralization.
• Biomaterial Science: Incorporated into coatings or matrices for implants and medical devices to prevent undesirable calcium phosphate deposition.
• Biochemistry & Enzymology: Serves as a substrate analog and inhibitor in studies of enzymes involved in phosphate metabolism and mineralization.

Basic Information

Product Name	Phosphocitrate
CAS No.	2565-87-9
Molecular Formula	C6H8O10P
Molecular Weight	280.10 g/mol
Synonyms	2-Phosphonatooxy-1,2,3-propanetricarboxylic acid; Citric acid phosphate; Phosphorylated citrate; Citric acid monophosphate; PC; 1-Phosphocitrate; NSC 266046; Phosphocitric acid
EINECS	219-902-7

Quality Control

Our Phosphocitrate is produced under a rigorous quality management system. Each batch is subjected to comprehensive analytical testing, including identification by FT-IR and NMR, purity assay by HPLC, and specific tests for residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
pH (1% solution)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.