Description

2-Iodoacetamide is a highly reactive alkylating agent widely used as a biochemical reagent for protein modification and enzyme inhibition. Its primary value lies in its ability to selectively modify cysteine residues, making it an indispensable tool for studying protein structure, function, and interactions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly in proteomics, drug discovery, and biochemical assay development.

Application

• Protein Biochemistry & Proteomics: A key reagent for alkylating cysteine thiol groups to prevent disulfide bond scrambling during protein sample preparation for mass spectrometry analysis.
• Enzyme Inhibition Studies: Used to irreversibly inhibit enzymes that rely on active-site cysteine residues, aiding in mechanistic studies and target validation.
• Bioconjugation & Protein Labeling: Serves as an intermediate for synthesizing fluorescent probes or affinity tags for labeling and tracking proteins.
• Pharmaceutical Research: Employed in the synthesis and development of novel drug candidates, particularly those targeting thiol-dependent pathways.
• Molecular Biology: Used to modify nucleic acid-binding proteins and other critical biomolecules to study their function.
• Quality Control in Biologics: Applied in analytical methods to characterize and ensure the consistency of therapeutic proteins.

Basic Information

Product Name	2-Iodoacetamide
CAS No.	144-48-9
Molecular Formula	C2H4INO
Molecular Weight	184.96 g/mol
Synonyms	Iodoacetamide; IAA; 2-Iodoacetamide; Iodoacetic acid amide; Acetamide, 2-iodo-; Iodoethanamide; α-Iodoacetamide; IAM
EINECS	205-630-1

Quality Control

Our 2-Iodoacetamide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific research or GMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its light-sensitive and easily oxidized nature, it is recommended to store the product under an inert atmosphere for long-term stability and to minimize decomposition. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92°C - 95°C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.