Antimetabolite Antineoplastic Agents
Antineoplastics
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Antimetabolite Antineoplastic Agents
Antimetabolite antineoplastic agents are structural analogs of nucleotides or essential metabolic substrates that disrupt DNA and RNA synthesis, leading to cell cycle arrest and apoptosis in rapidly dividing tumor cells. Major classes include antifolates, purine analogs, and pyrimidine analogs such as methotrexate, 5-fluorouracil, cytarabine, and gemcitabine. These agents interfere with thymidylate synthase, DNA polymerase, or folate pathways, making them cornerstone therapies in hematologic malignancies and solid tumors including colorectal cancer, lung cancer, and breast cancer. Their ability to selectively target fast-proliferating cells makes them highly effective, though toxicity to bone marrow and gastrointestinal tissues requires careful management.
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