Description

Glycinamide, L-asparaginyl-N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-D-2-(4-hydroxyphenyl)-, trihydrate, (2S-(2-alpha,5-alpha,6-beta))- is a complex, semi-synthetic β-lactam derivative of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key intermediate or precursor in the synthesis of novel cephalosporin-class antibiotics, offering a pathway to molecules with potentially enhanced efficacy and spectrum of activity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing next-generation anti-infective therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of advanced cephalosporin antibiotics.
• Antibiotic Research & Development: Used in medicinal chemistry programs to create and evaluate new β-lactam compounds with improved antibacterial properties.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialized, high-value active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in studies investigating the structure-activity relationships (SAR) of β-lactam antibiotics and mechanisms of bacterial resistance.

Basic Information

Product Name	Glycinamide, L-asparaginyl-N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-D-2-(4-hydroxyphenyl)-, trihydrate, (2S-(2-alpha,5-alpha,6-beta))-
CAS No.	85849-50-9
Molecular Formula	C22H29N5O9S · 3H2O
Molecular Weight	621.62 g/mol (Anhydrous basis: 567.56 g/mol)
Synonyms	(6R,7R)-7-[(2R)-2-Amino-2-(4-hydroxyphenyl)acetamido]-3-carbamoyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, L-Asparagine derivative; 7β-[2-(L-Asparaginyl)amino-2-(4-hydroxyphenyl)acetamido]-3-carbamoylceph-3-em-4-carboxylic acid trihydrate; Cephalosporin derivative intermediate; (6R,7R)-7-[(R)-2-Amino-2-(4-hydroxyphenyl)acetamido]-3-carbamoyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid compound with L-asparagine trihydrate
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and assay, spectroscopic identification (IR, NMR), and tests for residual solvents and water content (KF), to ensure consistency and traceability. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development projects with custom purity grades, from research (95%+) to GMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and opened under low-humidity conditions to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (Anhydrous basis)
Water Content (KF)	7.0% - 9.5% (Theoretical for trihydrate: ~8.7%)
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.