Description

Nafcillin CAS NO 147-52-4 is a semisynthetic, β-lactamase-resistant penicillin antibiotic. It is a critical pharmaceutical active ingredient valued for its efficacy against penicillinase-producing staphylococci. This compound is essential for manufacturers in the pharmaceutical industry developing injectable and oral antibiotic formulations to treat serious bacterial infections.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of injectable antibiotic solutions and oral dosage forms.
• Hospital & Clinical Formulations: Used in compounding sterile preparations for intravenous or intramuscular administration in hospital settings.
• Research & Development: Serves as a reference standard and key intermediate in antimicrobial research and new drug development projects.
• Veterinary Medicine: Employed in the formulation of antibiotics for treating bacterial infections in animals.
• Bulk Drug Substance: Supplied to generic pharmaceutical companies for the production of finished dosage forms.

Basic Information

Product Name	Nafcillin
CAS No.	147-52-4
Molecular Formula	C21H22N2O5S
Molecular Weight	414.48 g/mol
Synonyms	Nafcillin Sodium; (2S,5R,6R)-6-[[(2-Ethoxy-1-naphthoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-(2-Ethoxy-1-naphthamido)penicillanic acid; Ethoxynaphthamidopenicillanic acid; Wy-3277; Unipen; Naftopen; Nafcillinum
EINECS	205-686-1

Quality Control

Our Nafcillin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	+200° to +220° (c=1 in DMF)
pH (1% suspension)	5.0 - 7.5

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.