Description

Piperacillin is a broad-spectrum, β-lactam antibiotic belonging to the ureidopenicillin class. It is a critical active pharmaceutical ingredient (API) valued for its potent activity against a wide range of Gram-negative and Gram-positive bacteria, including Pseudomonas aeruginosa. This compound is essential for the pharmaceutical manufacturing sector, specifically for the formulation of injectable antibiotic combinations, such as piperacillin/tazobactam, used in hospital settings to treat serious infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable antibiotic formulations.
• Combination Drug Synthesis: Key starting material for the production of piperacillin sodium and the fixed-dose combination drug piperacillin/tazobactam.
• Hospital Infection Treatment: Used in medicines targeting intra-abdominal infections, urinary tract infections, septicemia, and nosocomial pneumonia.
• Research & Development: Serves as a reference standard and building block in antimicrobial research and new drug development.
• Veterinary Medicine: Potential application in developing treatments for bacterial infections in animals.

Basic Information

Product Name	Piperacillin
CAS No.	66258-76-2
Molecular Formula	C23H27N5O7S
Molecular Weight	517.56 g/mol
Synonyms	Piperacillin Free Acid; (2S,5R,6R)-6-[[(2R)-2-[[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Pipril; Pentcillin; Pipracil; T-1220; Avocin; Pipril; Pipracil
EINECS	266-304-9

Quality Control

Our Piperacillin is manufactured under strict quality management systems. It undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use. Specifications are aligned with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing purity, identity, and impurity profiles to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under conditions that prevent absorption of atmospheric moisture to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Specific Optical Rotation	+175° to +195° (c=1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.