Description

Methicillin Sodium Salt CAS NO 132-92-3 is a semisynthetic, β-lactamase-resistant penicillin antibiotic. It is a critical pharmaceutical intermediate and reference standard used in the development and quality control of antibiotic formulations. This compound is essential for research and manufacturing in the pharmaceutical industry, particularly for studying penicillin resistance mechanisms. Its primary value lies in its role as a model compound for penicillinase-stable antibiotics.

Application

• Pharmaceutical Intermediate: Key starting material or active component in the synthesis of specialized antibiotic formulations.
• Research & Development: Used as a reference standard in microbiological and pharmacological studies to investigate bacterial resistance, particularly against β-lactamase-producing strains.
• Quality Control & Analytical Testing: Serves as a certified reference material (CRM) for assay validation, impurity profiling, and HPLC/LC-MS method development in pharmaceutical QC laboratories.
• Microbiological Media: Employed in selective culture media for the isolation and identification of specific bacterial pathogens in clinical and research settings.
• Academic Research: Utilized in university and institutional labs for studies on antibiotic action, resistance mechanisms, and the history of antimicrobial development.

Basic Information

Product Name	Methicillin Sodium Salt
CAS No.	132-92-3
Molecular Formula	C17H19N2NaO6S
Molecular Weight	402.40 g/mol
Synonyms	Meticillin Sodium; Sodium Methicillin; Methicillin Sodium Salt Monohydrate; (2S,5R,6R)-6-[(2,6-Dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt; 6-(2,6-Dimethoxybenzamido)penicillanic acid sodium salt; BRL-1241; Celbenin Sodium; Staphicillin Sodium
EINECS	205-091-1

Quality Control

Our Methicillin Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency meet high-grade standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological tests is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0 %
pH (10% solution)	5.5 - 7.5
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Microbial Enumeration	Meets Ph. Eur. 2.6.12/2.6.13 criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.