Description

Penicillin F is a naturally occurring biosynthetic penicillin, also known as 2-Pentenylpenicillin, with the CAS registry number 118-53-6. This compound is of significant historical and research interest as one of the first penicillin variants identified, serving as a crucial reference standard and intermediate in pharmaceutical development. It is primarily utilized by research institutions, analytical laboratories, and manufacturers in the pharmaceutical and biotechnology sectors for method development, quality control, and the synthesis of advanced antibiotic derivatives.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments, method validation, and quality control testing in antibiotic manufacturing.
• Biochemical Research: Serves as a key intermediate or substrate in studies exploring penicillin biosynthesis, structure-activity relationships, and bacterial resistance mechanisms.
• Antibiotic Development: Acts as a precursor or a comparative compound in the research and development of novel β-lactam antibiotics and combination therapies.
• Analytical Chemistry: Employed in high-performance liquid chromatography (HPLC) and mass spectrometry (MS) as a known standard for identifying and quantifying penicillin-related impurities.
• Microbiology Studies: Used in in-vitro assays to study the potency, spectrum of activity, and degradation pathways of early-generation penicillins.

Basic Information

Item	Details
Product Name	Penicillin F
CAS No.	118-53-6
Molecular Formula	C14H20N2O4S
Molecular Weight	312.39 g/mol
Synonyms	2-Pentenylpenicillin; Pentenylpenicillin; Penicillin I; Flemicin F; 6-(2-Pentenamido)penicillanic acid; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-pentenoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
EINECS	204-260-1

Quality Control

Our Penicillin F is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by infrared spectroscopy (IR) and assay by HPLC, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent internal specifications. We support cGMP practices for materials intended for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.