Description

Calcium [2S-Cis(2Alpha,5Alpha,6Beta)]-Bis[3,3-Dimethyl-7-Oxo-6-[(Phenoxyacetyl)Amino]-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate] is the calcium salt of a semi-synthetic penicillin derivative, specifically the calcium salt of phenoxymethylpenicillinic acid. This compound is valued for its role as a key pharmaceutical intermediate in the synthesis of broad-spectrum penicillin antibiotics. It is primarily required by manufacturers in the pharmaceutical and fine chemical sectors for the production of oral antibiotic formulations.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A critical building block in the synthesis of penicillin V (phenoxymethylpenicillin) and related β-lactam antibiotics.
• Pharmaceutical Manufacturing: Used in the production of oral dosage forms such as tablets, capsules, and powders for antibiotic medications.
• Veterinary Medicine: Employed in the formulation of antibacterial treatments for livestock and companion animals.
• Research & Development: Serves as a reference standard and starting material in microbiological and pharmacological research for new antibiotic compounds.
• Fine Chemical Synthesis: Utilized in specialized organic synthesis to create novel penicillin analogs and derivatives with modified properties.

Basic Information

Product Name	Calcium [2S-Cis(2Alpha,5Alpha,6Beta)]-Bis[3,3-Dimethyl-7-Oxo-6-[(Phenoxyacetyl)Amino]-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate]
CAS No.	147-48-8
Molecular Formula	C34H34CaN4O10S2
Molecular Weight	770.86 g/mol
Synonyms	Calcium Phenoxymethylpenicillinate; Penicillin V Calcium Salt; Phenoxymethylpenicillin Calcium; Calcium (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; Calcium Benzylpenicillin Phenoxymethyl Ester; Fenossimetilpenicillina Calcio; Kalzium-Phenoxymethylpenicillin; CAS 147-48-8
EINECS	205-699-2

Quality Control

Our Calcium Phenoxymethylpenicillinate is manufactured under strict quality systems to ensure it meets the rigorous standards required for pharmaceutical intermediates. Quality is assured through comprehensive analytical testing, including HPLC for purity and related substances, and microbiological testing. We provide full traceability and Certificates of Analysis (COA) with each batch, confirming compliance with in-house specifications aligned with major pharmacopoeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
pH (5% aqueous suspension)	5.0 - 7.5
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Microbial Enumeration	Meets standard bioburden limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.