Description

(2S,5R,6R)-6-[[(2R)-2-[[(2R)-2-(o-Nitrophenylthioamino)-3-(N-methylcarbamoyl)propionyl]amino]-2-(p-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid CAS NO 63359-73-9 is a sophisticated, high-purity advanced pharmaceutical intermediate (API intermediate) with a complex β-lactam core structure. This compound is critical for research and development in the synthesis of novel cephalosporin antibiotics, offering a key chiral building block for creating targeted antimicrobial agents. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on developing next-generation antibacterial therapies.

Application

• Key Intermediate in Cephalosporin Synthesis: Serves as a crucial precursor in the multi-step synthesis of advanced cephalosporin antibiotic candidates.
• Pharmaceutical R&D: Used in medicinal chemistry programs for the design, optimization, and structure-activity relationship (SAR) studies of new β-lactam antibiotics.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for novel antibiotic production in pilot plants.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional research projects investigating new mechanisms of antibacterial action and resistance.
• Fine Chemical Manufacturing: Supplied to custom synthesis organizations for the production of specialized, low-volume antibiotic analogs.

Basic Information

Product Name	(2S,5R,6R)-6-[[(2R)-2-[[(2R)-2-(o-Nitrophenylthioamino)-3-(N-methylcarbamoyl)propionyl]amino]-2-(p-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS No.	63359-73-9
Molecular Formula	C31H34N6O8S2
Molecular Weight	682.77 g/mol
Synonyms	6-[[(2R)-2-[[(2R)-2-[(2-Nitrophenyl)thio]amino]-3-(methylcarbamoyl)-1-oxopropyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Cephalosporin C derivative intermediate; 7-ACA derivative with o-nitrophenylthio side chain; β-Lactam antibiotic intermediate; (6R,7R)-7-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid derivative; Advanced cephalosporin synthon; CAS 63359-73-9
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications can be aligned with USP/EP monograph standards for related compounds upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below for long-term stability. For short-term use, storage at 2-8°C is acceptable. This compound is easily oxidized; containers should be sealed under an inert atmosphere (nitrogen or argon) after opening and protected from moisture. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.