Description

4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(phenylacetyl)amino- (2S,5R,6R)-, compd. with N,N-bis(phenylmethyl)-1,2-ethanediamine (2:1), monohydrate is a high-purity pharmaceutical intermediate and a critical salt form of a β-lactam antibiotic precursor. This compound is essential for ensuring the stability, bioavailability, and manufacturability of active pharmaceutical ingredients (APIs) in final dosage forms. It is primarily required by manufacturers in the pharmaceutical and fine chemical industries for the synthesis of advanced antibiotic formulations.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of penicillin-derived antibiotics and other β-lactam drugs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of specific antibiotic APIs where the benzathine salt form is required for prolonged action.
• Research & Development: Serves as a critical reference standard and starting material in antimicrobial drug discovery and process chemistry.
• Veterinary Medicine: Employed in the formulation of long-acting injectable antibiotic treatments for animals.
• Fine Chemical Synthesis: Utilized in specialized organic synthesis for constructing complex molecular architectures containing the β-lactam core.

Basic Information

Product Name	4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(phenylacetyl)amino- (2S,5R,6R)-, compd. with N,N-bis(phenylmethyl)-1,2-ethanediamine (2:1), monohydrate
CAS No.	5928-83-6
Molecular Formula	C16H18N2O4S • ½ C16H20N2 • H2O
Molecular Weight	Contact for details
Synonyms	Benzathine Benzylpenicillin Impurity; Penicillin G Benzathine Monohydrate; Benzathine Penicillin G Monohydrate; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compound with N,N'-dibenzylethylenediamine (2:1) monohydrate; N,N'-Dibenzylethylenediamine benzylpenicillin (2:1) salt monohydrate; Benzylpenicillin Benzathine Monohydrate; Antibiotic Benzathine Salt
EINECS	Contact for details

Quality Control

Our 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(phenylacetyl)amino- (2S,5R,6R)-, compd. with N,N-bis(phenylmethyl)-1,2-ethanediamine (2:1), monohydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting standards relevant for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation or clumping.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	2.0% - 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.