Description

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]- is a chemically modified penicillin derivative, specifically a prodrug ester of hetacillin. This compound is a key pharmaceutical intermediate, valued for its role in the synthesis of broad-spectrum antibiotics. It is primarily utilized by manufacturers in the pharmaceutical industry for the research, development, and production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of hetacillin and related β-lactam antibiotics.
• API Development: Used in research and development for creating new antibiotic formulations and combination therapies.
• Chemical Synthesis: Serves as a precursor in advanced organic synthesis for modifying penicillin core structures.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method validation and impurity profiling.
• Antibiotic Research: Used in microbiological and pharmacological studies to investigate structure-activity relationships (SAR) of β-lactam compounds.

Basic Information

Product Name	4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]-
CAS No.	32887-03-9
Molecular Formula	C22H35N3O5S · HCl
Molecular Weight	490.06 g/mol
Synonyms	Hetacillin Pivaloyloxymethyl Ester Hydrochloride; Pivmecillinam Hydrochloride (common); Amdinocillin Pivoxil Hydrochloride; FL 1039 Hydrochloride; Selexid Hydrochloride; Mecillinam Pivoxil Hydrochloride; 6β-[(Hexahydro-1H-azepin-1-yl)methyleneamino]penicillanic acid pivaloyloxymethyl ester hydrochloride; [2S-(2α,5α,6β)]-
EINECS	Contact for details

Quality Control

Our 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-3,3-dimethyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl ester, monohydrochloride, [2S-(2alpha,5alpha,6beta)]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.