Description

1-[(2S)-2-[(6-Methyl-1-oxoheptyl)amino]-4-[(sulfomethyl)amino]butanoic acid]-3-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]-5-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]-9-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]polymyxin E2 is a defined, high-purity congener of the polymyxin class of polypeptide antibiotics. This compound is critical for advanced pharmaceutical research and development, particularly in the study of last-resort antibiotics against multidrug-resistant Gram-negative bacteria. It is essential for academic institutions, pharmaceutical R&D laboratories, and reference standard producers focused on antimicrobial mechanisms, resistance studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quality control and assay of polymyxin E (Colistin) APIs and finished drug products.
• Antimicrobial Research: Serves as a key tool in microbiological studies to investigate the structure-activity relationship (SAR) of polymyxin antibiotics.
• Mechanistic Studies: Employed in biochemical research to elucidate the mode of action against bacterial cell membranes and the basis of bacterial resistance.
• Analytical Method Development: Used to develop and validate precise HPLC, LC-MS, and other chromatographic methods for polymyxin analysis.
• Preclinical Development: Supports toxicology, pharmacokinetics, and pharmacodynamics studies for next-generation polymyxin-based therapies.

Basic Information

Product Name	1-[(2S)-2-[(6-Methyl-1-oxoheptyl)amino]-4-[(sulfomethyl)amino]butanoic acid]-3-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]-5-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]-9-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]polymyxin E2
CAS No.	30387-41-8
Molecular Formula	C53H100N16O13S4
Molecular Weight	1281.8 g/mol (approx.)
Synonyms	Polymyxin E2; Colistin E2; Colistin component E2; Polymyxin E (Colistin) Congener E2; [Dab1, Ser3]polymyxin E2; Antibiotic A 202 E2; Cyclo[[(2S)-2-[(6-methyl-1-oxoheptyl)amino]-4-[(sulfomethyl)amino]butanoyl]-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoyl]-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoyl]-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoyl]-[Gly-D-Thr-γ-D-Leu-D-Leu-D-Leu]]
EINECS	Contact for details

Quality Control

Our 1-[(2S)-2-[(6-Methyl-1-oxoheptyl)amino]-4-[(sulfomethyl)amino]butanoic acid]-3-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]-5-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]-9-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]polymyxin E2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and reference standard use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.