Description

(2S,5β)-6α-[[(S)-[[[(2-Furanylcarbonyl)amino]carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid potassium salt is a high-purity, semi-synthetic β-lactam compound primarily utilized as a key intermediate in advanced pharmaceutical synthesis. This compound is critical for ensuring the structural integrity and bioactivity of final active pharmaceutical ingredients (APIs) in the penicillin and cephalosporin class. It is essential for manufacturers in the pharmaceutical industry requiring precise and reliable building blocks for antibiotic research, development, and production.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel β-lactam antibiotics and related therapeutic agents.
• Antibiotic Research & Development: Used in medicinal chemistry for the design, modification, and structure-activity relationship (SAR) studies of new antimicrobial compounds.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in controlled synthesis processes to produce bulk pharmaceutical compounds under GMP conditions.
• Biochemical Research: Acts as a standard or reference material in studies investigating bacterial resistance mechanisms and enzyme inhibition (e.g., penicillin-binding proteins).
• Process Chemistry: Utilized for scaling up production processes and optimizing yield and purity for commercial-scale API manufacturing.

Basic Information

Product Name	(2S,5β)-6α-[[(S)-[[[(2-Furanylcarbonyl)amino]carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid potassium salt
CAS No.	25673-17-0
Molecular Formula	C23H23KN4O7S
Molecular Weight	538.62 g/mol
Synonyms	6-APA derivative potassium salt; Potassium (2S,5R,6R)-6-[(2R)-2-[[(2-Furoylamino)carbonyl]aminoacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; 6-[(Phenyl(2-[(2-furoylamino)carbonyl]amino)acetyl)amino]penicillanic acid potassium salt; Penicillin G potassium salt derivative; Furoylurea penicillanic acid potassium salt; Potassium 6β-(2-furoylureido)benzylpenicillinate; 6-[D-α-(2-Furoylureido)benzamido]penicillanic acid potassium salt
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to stringent quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods, and control of specified impurities to ensure it meets the exacting standards required for API synthesis. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards (USP/EP) where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. The storage area should be well-ventilated and separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Potassium Content	Conforms to theoretical value

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.