Description

[(2R)-2-(6-Benzamidopurin-9-yl)-2-[(2R)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropan-2-yl]oxyethyl] benzoate is a high-purity, phosphoramidite-protected nucleoside derivative essential for automated oligonucleotide synthesis. This compound serves as a critical building block for the precise and efficient assembly of DNA and RNA sequences, ensuring high coupling efficiency and fidelity. It is primarily required by biotechnology, pharmaceutical, and diagnostic research sectors for applications in antisense therapy, siRNA development, PCR primers, and genetic analysis.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of DNA and RNA strands in research and therapeutic development.
• Antisense Oligonucleotide (ASO) Manufacturing: For the production of therapeutic oligonucleotides targeting specific mRNA sequences to modulate gene expression.
• Small Interfering RNA (siRNA) Production: A crucial raw material in the synthesis of siRNA molecules used in RNA interference (RNAi) research and therapeutics.
• Diagnostic Probe Synthesis: Used to manufacture labeled probes for techniques like fluorescence in situ hybridization (FISH) and real-time PCR.
• Primer and Library Construction: For synthesizing high-fidelity primers for PCR, sequencing, and the construction of genomic libraries.
• Research & Development: Enables academic and industrial R&D in genomics, molecular biology, and novel nucleic acid-based drug discovery.

Basic Information

Product Name	[(2R)-2-(6-Benzamidopurin-9-yl)-2-[(2R)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropan-2-yl]oxyethyl] benzoate
CAS No.	1120329-52-3
Molecular Formula	C58H62N7O9P
Molecular Weight	1024.13 g/mol
Synonyms	2'-Deoxyadenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[2-cyanoethoxy]diisopropylaminophosphinyl]-3'-O-[(2R)-2-[(benzoyloxy)methyl]-4-pentenyl]-, 2-Cyanoethyl Phosphoramidite; N-Bz-dA(bz) Phosphoramidite (DMT protected); 2'-Deoxyadenosine, N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[[[2-cyanoethoxy]diisopropylaminophosphinyl]-3'-O-[(2R)-2-[(benzoyloxy)methyl]-4-pentenyl]-; dA(Bz) Phosphoramidite; Protected Deoxyadenosine Phosphoramidite; DNA Synthesis Reagent
EINECS	Contact for details

Quality Control

Our [(2R)-2-(6-Benzamidopurin-9-yl)-2-[(2R)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropan-2-yl]oxyethyl] benzoate is manufactured under strict quality systems to meet the exacting standards of oligonucleotide synthesis. Each batch undergoes comprehensive analytical testing, including HPLC, 31P NMR, and 1H NMR, to ensure identity, purity, and performance. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical research and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This material is hygroscopic (moisture-sensitive) and easily oxidized. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.