Description

Poly(2-Aminodeoxyadenylate-5-Bromodeoxyuridylate) is a synthetic, sequence-defined oligonucleotide analog, a key research tool in molecular biology and nucleic acid chemistry. Its precise structure, incorporating modified adenine and uracil bases, makes it invaluable for studying DNA-protein interactions, antisense mechanisms, and as a model for modified genetic material. This compound is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in advanced genomic studies, therapeutic oligonucleotide development, and diagnostic probe design.

Application

• Antisense & Gene Silencing Research: Serves as a model compound for investigating the mechanism and efficacy of antisense oligonucleotides designed to target specific mRNA sequences.
• Nucleic Acid-Protein Interaction Studies: Used to probe the binding specificity and affinity of proteins, enzymes, and transcription factors to modified DNA sequences.
• Therapeutic Oligonucleotide Development: Acts as a precursor or analog in the research and development of novel oligonucleotide-based therapeutics, including aptamers and siRNA.
• Diagnostic Probe Synthesis: Employed in the design and validation of high-specificity probes for genetic testing, fluorescence in situ hybridization (FISH), and microarray technologies.
• Biochemical & Biophysical Research: Utilized in studies examining the stability, hybridization kinetics, and structural properties of chemically modified DNA duplexes.
• Academic & Pharmaceutical R&D: A critical reagent for universities, contract research organizations (CROs), and drug discovery labs focusing on molecular genetics and targeted therapies.

Basic Information

Item	Detail
Product Name	Poly(2-Aminodeoxyadenylate-5-Bromodeoxyuridylate)
CAS No.	104576-80-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Poly(dA-dU) analog; Poly(2-aminodeoxyadenylic-5-bromodeoxyuridylic acid); Bromodeoxyuridylate-aminodeoxyadenylate copolymer; Modified poly(dA-dU); 5-BrdU-2-NH2-dA copolymer; Sequence-defined oligonucleotide polymer; Research oligonucleotide 104576-80-9
EINECS	Contact for details

Quality Control

Every batch of Poly(2-Aminodeoxyadenylate-5-Bromodeuridylate) is produced and analyzed under stringent quality protocols to ensure consistency and reliability for critical research applications. Our quality assurance includes verification of sequence integrity, base composition, and purity levels suitable for biochemical studies. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), molecular weight distribution, and other relevant parameters is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Base Ratio (A:U)	~1:1 (by HPLC analysis)
Moisture Content (KF)	≤ 5.0%
Solubility	Soluble in aqueous buffers, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.