Description

5-(Aminomethyl)-2-Thiouridine is a modified nucleoside analog characterized by the presence of an aminomethyl group at the 5-position and a sulfur substitution at the 2-position of the uracil base. This unique structure makes it a valuable building block and intermediate in advanced biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of medicinal chemistry, oligonucleotide synthesis, and the development of novel therapeutic agents.

Application

• Medicinal Chemistry Intermediate: Serves as a key precursor in the synthesis of novel nucleoside-based drug candidates, including potential antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used in the solid-phase or solution-phase synthesis of modified RNA and DNA strands to study structure-function relationships and enhance stability.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of nucleoside-metabolizing enzymes.
• Antisense Technology: Incorporated into antisense oligonucleotides to modulate gene expression with potentially improved binding affinity or nuclease resistance.
• Probe Development: Utilized in the creation of labeled nucleosides for diagnostic assays and imaging techniques.
• Academic & Institutional Research: Fundamental research tool for studying nucleic acid chemistry, modification effects, and metabolic pathways.

Basic Information

Product Name	5-(Aminomethyl)-2-Thiouridine
CAS No.	109666-14-0
Molecular Formula	C10H15N3O5S
Molecular Weight	289.31 g/mol
Synonyms	2-Thio-5-(aminomethyl)uridine; 5-(Aminomethyl)-2-thiouridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(aminomethyl)-2-thioxo-1,2-dihydropyrimidin-4-one; 2-Thiouridine, 5-(aminomethyl)-; 5-(Aminomethyl)-2-thio-uridine; 5-(Aminomethyl)-2-thio-Urd
EINECS	Contact for details

Quality Control

Our 5-(Aminomethyl)-2-Thiouridine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to minimize moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.