Description

Poly(2-Aminodeoxyadenylate-5-Iododeoxyuridylate) is a synthetic polynucleotide analog with a defined alternating sequence. This compound is significant for its role as a specialized research reagent in molecular biology and biochemistry, particularly in studies involving nucleic acid structure, function, and interactions. It is primarily utilized by pharmaceutical R&D teams and academic research institutions focused on antiviral mechanisms, antisense technology, and advanced oligonucleotide-based therapeutics.

Application

• Biochemical Research: Used as a model compound for studying the biophysical properties and hybridization behavior of modified DNA/RNA strands.
• Antiviral Mechanism Studies: Serves as a substrate or inhibitor in enzymatic assays to investigate viral polymerase activity and nucleoside analog incorporation.
• Antisense & Aptamer Development: Acts as a precursor or template in the research and development of novel antisense oligonucleotides and nucleic acid aptamers with enhanced stability.
• Diagnostic Probe Synthesis: Employed in the development of specialized, labeled nucleic acid probes for sensitive detection and diagnostic applications.
• Polymerase Chain Reaction (PCR) Optimization: Used in controlled experiments to understand the impact of nucleotide modifications on PCR fidelity and efficiency.
• Material Science for Nanobiotechnology: Investigated for its potential in constructing functional nanostructures and biomaterials due to its programmable sequence.

Basic Information

Product Name	Poly(2-Aminodeoxyadenylate-5-Iododeoxyuridylate)
CAS No.	104576-78-5
Molecular Formula	(C10H12IN5O6P • C9H11N2O8P)n
Molecular Weight	Contact for details (Polymer)
Synonyms	Poly(dA-2-NH2-dU-5-I); Poly(2-Amino-2'-deoxyadenylyl-(3'→5')-5-iodo-2'-deoxyuridylyl); Alternating d(A2-NH2-U5-I) copolymer; Poly(2-aminodeoxyadenylic acid-5-iododeoxyuridylic acid); 2-Aminodeoxyadenosine-5-iododeoxyuridine copolymer; Poly(dA2-NH2-dU5-I); d(A2-NH2,U5-I) polynucleotide; Poly(2-NH2-dA:5-I-dU)
EINECS	Contact for details

Quality Control

Our Poly(2-Aminodeoxyadenylate-5-Iododeoxyuridylate) is produced under controlled conditions to ensure batch-to-batch consistency for critical research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification. Certificates of Analysis (COA) detailing purity, sequence verification, and other relevant parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (UV/VIS)	Complies
Identification (HPLC)	Complies
Purity (HPLC)	≥ 95%
Sequence Integrity (CE or PAGE)	Alternating copolymer, main peak
Water Content (KF)	≤ 5.0 %
Extinction Coefficient (ε260)	Provided per batch
Molecular Weight Range	Provided per batch (e.g., 10-50 mer)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.