Description

2'-Deoxythymidylyl-(3'-5')-2'-Deoxyadenosine is a defined dinucleotide, specifically a thymidylyl-adenosine dimer, which serves as a fundamental building block in nucleic acid chemistry. This compound is crucial for research and development in the fields of molecular biology and medicinal chemistry, where precise oligonucleotide synthesis is required. It is primarily utilized by biotech and pharmaceutical R&D teams, as well as academic laboratories, for applications ranging from probe development to the study of DNA structure and function.

Application

• Oligonucleotide Synthesis: Acts as a key intermediate or reference standard in the solid-phase or solution-phase synthesis of custom DNA sequences.
• Biochemical Research: Used as a substrate or model compound in enzymatic studies involving nucleases, ligases, and polymerases.
• Probe Development: Serves as a core component in the design and construction of labeled probes for hybridization assays and diagnostic applications.
• Medicinal Chemistry: Employed in the research and development of antisense oligonucleotides, aptamers, and other therapeutic nucleic acid analogs.
• Quality Control & Standardization: Functions as a high-purity analytical standard for the calibration and validation of HPLC, MS, or other analytical methods in QC laboratories.
• Academic Studies: Utilized in university research to investigate DNA duplex stability, base-pairing interactions, and the physicochemical properties of nucleic acids.

Basic Information

Product Name	2'-Deoxythymidylyl-(3'-5')-2'-Deoxyadenosine
CAS No.	19192-40-6
Molecular Formula	C20H25N7O12P2
Molecular Weight	617.41 g/mol
Synonyms	d(TpA); TpdeA; Thymidylyl(3'→5')deoxyadenosine; 2'-Deoxyadenylyl-(5'→3')-2'-deoxythymidine; d(TpA) dinucleotide; Deoxythymidylyl-deoxyadenosine; T-A Dinucleotide; pd(T-A)
EINECS	Contact for details

Quality Control

Our 2'-Deoxythymidylyl-(3'-5')-2'-Deoxyadenosine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals, and specifications can be tailored to meet specific research-grade or higher purity requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.