Description

5'-Phosphoryl-(3'-Amino-3'-Deoxycytidylyl)-(3'-5')-3'-Amino-3'-Deoxyguanosine is a chemically modified dinucleotide, a key building block in advanced oligonucleotide synthesis. This compound is critical for research and development in nucleic acid chemistry, enabling the creation of oligonucleotides with enhanced stability and specific functional properties. It is primarily utilized by researchers and manufacturers in the fields of therapeutic oligonucleotide development, diagnostic probe design, and fundamental biochemical studies.

Application

• Therapeutic Oligonucleotide Synthesis: A crucial phosphoramidite precursor for constructing modified antisense oligonucleotides (ASOs), siRNA, and aptamers with nuclease resistance.
• Diagnostic Probe Development: Used in the creation of highly specific and stable fluorescent or labeled probes for in situ hybridization (ISH) and PCR applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of nucleotidyltransferases and polymerases.
• Structural Biology Studies: Incorporated into oligonucleotides for X-ray crystallography or NMR studies to understand nucleic acid-protein interactions.
• Next-Generation Sequencing (NGS): Potential use in developing novel sequencing primers or adapters with modified bases to improve sequencing efficiency.

Basic Information

Product Name	5'-Phosphoryl-(3'-Amino-3'-Deoxycytidylyl)-(3'-5')-3'-Amino-3'-Deoxyguanosine
CAS No.	109679-55-2
Molecular Formula	C19H27N9O12P2
Molecular Weight	643.43 g/mol
Synonyms	3'-Amino-3'-deoxyCpG (5'-phosphate); pdCpG(3'-NH2); 5'-Phospho-3'-amino-d(CpG); 3'-Amino-dinucleotide CpG phosphate; 3'-Amino-2'-deoxycytidylyl-(3'→5')-3'-amino-2'-deoxyguanosine 5'-phosphate; Amino-modified CpG dinucleotide; CpG-NH2 dinucleotide phosphate
EINECS	Contact for details

Quality Control

Our 5'-Phosphoryl-(3'-Amino-3'-Deoxycytidylyl)-(3'-5')-3'-Amino-3'-Deoxyguanosine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, desiccate and keep under inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Conforms to ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.