Description

(2S,5R,6R)-6α-[[[[(3,4-Dihydroxybenzoyl)(3-hydroxypropyl)amino]carbonyl]aminoacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid is a sophisticated, semi-synthetic penicillin derivative, representing a key advanced intermediate in modern pharmaceutical synthesis. Its complex structure is engineered to serve as a crucial building block for the development of next-generation β-lactam antibiotics with enhanced efficacy and resistance profiles. This high-purity compound is essential for research institutions and manufacturers focused on antibiotic discovery, process development, and the production of novel therapeutic agents targeting resistant bacterial strains.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of advanced penicillin and cephalosporin analogs.
• Antibiotic Research & Development (R&D): Serves as a key scaffold for medicinal chemists exploring new structures to overcome bacterial resistance mechanisms.
• Process Chemistry: Used in the development and scale-up of manufacturing routes for novel β-lactam antibiotics.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Bioconjugation Studies: Potential use in creating targeted antibiotic conjugates due to its functionalized side chain.

Basic Information

Product Name	(2S,5R,6R)-6α-[[[[(3,4-Dihydroxybenzoyl)(3-hydroxypropyl)amino]carbonyl]aminoacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid
CAS No.	112421-25-7
Molecular Formula	C27H30N4O9S
Molecular Weight	586.61 g/mol
Synonyms	6-APA derivative with 3,4-dihydroxybenzoyl and 3-hydroxypropylcarbamoyl groups; Penicillin G derivative, modified; 6-[(Carbamoyl{[(3,4-dihydroxybenzoyl)(3-hydroxypropyl)amino]carbonyl}amino)(phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Advanced Penicillin Intermediate; β-lactam antibiotic intermediate; (2S,5R,6R)-6-[[(2R)-2-Amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid derivative
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D and synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.