Description

[(2R,3S,4R,5R)-4-amino-2-[[(2R,3S,4R,5R)-4-amino-5-(4-amino-2-oxo-pyrimidin-1-yl)-3-phosphonooxy-oxolan-2-yl]methoxymethyl]-5-(2-amino-6-oxo-3H-purin-9-yl)oxolan-3-yl]oxyphosphonic acid is a high-purity, complex nucleoside phosphate derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block or intermediate for the synthesis of novel antiviral and anticancer agents, particularly nucleotide analogs. It is essential for research institutions, biotechnology firms, and pharmaceutical companies engaged in the discovery and production of next-generation therapeutics targeting viral replication and cellular proliferation.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleotide analog drugs for antiviral (e.g., hepatitis, HIV) and anticancer therapies.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and nucleotide processing.
• Pro-drug Development: Serves as a core structure for designing membrane-permeable pro-drugs that are activated intracellularly.
• Antiviral Agent Synthesis: Critical for constructing active pharmaceutical ingredients (APIs) that mimic natural nucleotides to inhibit viral polymerases.
• Labeled Compound Production: Basis for synthesizing isotopically labeled (e.g., 13C, 15N, 32P) versions for pharmacokinetic and metabolic tracing studies.
• Molecular Biology Tools: Potential use in creating specialized probes or primers for advanced diagnostic assays.

Basic Information

Product Name	[(2R,3S,4R,5R)-4-amino-2-[[(2R,3S,4R,5R)-4-amino-5-(4-amino-2-oxo-pyrimidin-1-yl)-3-phosphonooxy-oxolan-2-yl]methoxymethyl]-5-(2-amino-6-oxo-3H-purin-9-yl)oxolan-3-yl]oxyphosphonic acid
CAS No.	109679-54-1
Molecular Formula	C19H28N9O14P2
Molecular Weight	668.42 g/mol
Synonyms	1-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1,4-dideoxy-1,4-imino-2-O-methyl-D-ribitol 3,5-bis(dihydrogen phosphate); 2'-O-Methyl-ADP; 2'-O-Methyladenosine 3',5'-bisphosphate; 2'-O-Methyladenosine diphosphate; Adenosine 2'-O-methyl-3',5'-diphosphate; 2'-O-Me-ADP; 9-[(2R,3S,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(4-Amino-2-oxo-1-pyrimidinyl)-3,4-dihydroxy-2-tetrahydrofuranyl]methoxy]methyl]-3,4-dihydroxy-2-tetrahydrofuranyl]-6-amino-9H-purin-2-one 3',5'-bis(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our [(2R,3S,4R,5R)-4-amino-2-[[(2R,3S,4R,5R)-4-amino-5-(4-amino-2-oxo-pyrimidin-1-yl)-3-phosphonooxy-oxolan-2-yl]methoxymethyl]-5-(2-amino-6-oxo-3H-purin-9-yl)oxolan-3-yl]oxyphosphonic acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a desiccated environment to prevent moisture absorption, which can compromise stability. For long-term storage, consider conditions of 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.