Description

2-Methylenebutanedioic acid 1-[(1R,3R,5S,6R)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-6-yl]4-[(1R,3R,5S,6R)-8-methyl-6-[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]-8-azabicyclo[3.2.1]octan-3-yl] ester is a complex, high-purity synthetic intermediate with a defined stereochemistry. This compound is critical for advanced pharmaceutical research and development, particularly in the synthesis of specialized active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, especially those targeting neurological and receptor-specific pathways.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new therapeutic candidates.
• Process Chemistry: Serves as a critical chiral precursor in the development and scale-up of GMP manufacturing processes for APIs.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Bioconjugation Chemistry: Potential use in creating targeted drug conjugates or probes due to its reactive ester and functional group handles.
• Asymmetric Synthesis: Utilized in stereoselective synthesis to construct complex molecular architectures found in natural products and pharmaceuticals.

Basic Information

Product Name	2-Methylenebutanedioic acid 1-[(1R,3R,5S,6R)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-6-yl]4-[(1R,3R,5S,6R)-8-methyl-6-[[(Z)-2-methyl-1-oxo-2-butenyl]oxy]-8-azabicyclo[3.2.1]octan-3-yl] ester
CAS No.	109031-04-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(3-endo,8-anti)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl (Z)-2-methyl-2-butenoate, 4-[[(3-endo,8-anti)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]oct-6-yl]oxy]-4-oxo-2-butenoate (9CI); Tropane-3-ol, 6-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-, 4-[(3-endo,8-anti)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]oct-6-yl] 2-methylenesuccinate; 2-Butenoic acid, 2-methyl-, (3-endo,8-anti)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, 4-[[(3-endo,8-anti)-3-hydroxy-8-methyl-8-azabicyclo[3.2.1]oct-6-yl]oxy]-4-oxo-; 109031-04-1; Tropisetron Impurity; Tropisetron Related Compound
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is analyzed to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific test results are available upon request. We adhere to stringent internal specifications suitable for research and pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.