Description

Naltrexone CAS NO 16590-41-3 is a potent opioid receptor antagonist of significant pharmaceutical importance. It is a critical active pharmaceutical ingredient (API) used to block the effects of opioids and is also utilized in the treatment of alcohol dependence. This compound is essential for manufacturers in the pharmaceutical and biotechnology sectors developing addiction management therapies. Its high purity and consistent quality are paramount for ensuring the safety and efficacy of the final medicinal products.

Application

• Pharmaceutical API: Primary use as the active ingredient in medications for opioid dependence (e.g., in oral tablets and extended-release injectable formulations).
• Alcohol Use Disorder Treatment: Key component in pharmaceuticals approved to reduce alcohol craving and consumption.
• Research Chemical: Used in preclinical and clinical research to study opioid receptor pathways, addiction mechanisms, and neuropharmacology.
• Formulation Development: Serves as a reference standard and raw material for developing generic and novel drug delivery systems.
• Veterinary Medicine: Potential application in veterinary settings for managing opioid-related issues in animals.

Basic Information

Product Name	Naltrexone
CAS No.	16590-41-3
Molecular Formula	C20H23NO4
Molecular Weight	341.41 g/mol
Synonyms	17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one; EN-1639A; Naltrexonum; Nalorex; Depade; ReVia; Vivitrol; Antaxon; Trexan
EINECS	240-654-6

Quality Control

Our Naltrexone is manufactured and tested under strict quality management systems to meet the rigorous standards of the pharmaceutical industry. We offer grades compliant with major pharmacopoeial monographs, including USP and EP. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring full traceability and regulatory compliance for global markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container in a well-ventilated area and away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Specific Rotation	-170° to -181° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.