Description

Risdiplam is a small molecule splicing modifier of the survival motor neuron 2 (SMN2) gene, identified by the CAS number 1825352-65-5. It is a critical therapeutic agent designed to increase functional SMN protein levels in the body. This product is essential for pharmaceutical manufacturers and research institutions developing treatments for spinal muscular atrophy (SMA).

Application

• Active Pharmaceutical Ingredient (API) for the formulation of oral SMA therapeutics.
• Reference Standard in analytical method development and validation for quality control laboratories.
• Research & Development material for preclinical and clinical studies in neurodegenerative diseases.
• Process Development for optimizing synthesis and scale-up manufacturing routes.
• Regulatory Submissions, supporting documentation for new drug applications (NDA) and marketing authorization.

Basic Information

Product Name	Risdiplam
CAS No.	1825352-65-5
Molecular Formula	C22H23N7O4
Molecular Weight	449.46 g/mol
Synonyms	RG7916; RO7034067; 7-(4,7-Diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione; Evrysdi (brand name)
EINECS	Contact for details

Quality Control

Our Risdiplam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency meet stringent pharmaceutical standards. A detailed Certificate of Analysis (COA) with full specification data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccated environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.10%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.