Description

Zenarestat is a potent and selective aldose reductase inhibitor (ARI) of significant interest in pharmaceutical research and development. This compound is crucial for investigating biochemical pathways related to diabetic complications, particularly neuropathy and retinopathy. It is primarily utilized by pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in metabolic disorder research and novel therapeutic discovery.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies targeting diabetic complications.
• Biochemical Pathway Investigation: Used in vitro and in vivo to study the polyol pathway and the role of aldose reductase in hyperglycemia-induced cellular damage.
• Drug Discovery Programs: Serves as a critical tool compound for screening, validating new ARI candidates, and understanding structure-activity relationships (SAR).
• Analytical Standard: Employed as a high-purity certified reference material (CRM) for quality control and method development in analytical laboratories (HPLC, LC-MS).
• Academic Research: Utilized in university and institutional labs for fundamental research into metabolic diseases and oxidative stress mechanisms.

Basic Information

Product Name	Zenarestat
CAS No.	112733-06-9
Molecular Formula	C₁₅H₁₀F₃N₃O₃
Molecular Weight	337.25 g/mol
Synonyms	FK-366; FR-74366; Zenarestat (USAN); (S)-6-Fluoro-2',3'-dihydrospiro[chroman-4,4'-imidazolidine]-2,5'-dione; (4S)-6-Fluoro-2,3-dihydro-4H-1-benzopyran-4-spiro-4'-imidazolidine-2',5'-dione; Aldose Reductase Inhibitor FK-366; Spiro[chroman-4,4'-imidazolidine]-2,5'-dione, 6-fluoro-2',3'-dihydro-, (4S)-
EINECS	Contact for details

Quality Control

Our Zenarestat is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We support compliance with cGMP guidelines for API manufacturing where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.