Description

Enadoline CAS NO 107431-28-7 is a potent, selective kappa opioid receptor (KOR) agonist, a compound of significant interest in advanced pharmacological research. Its primary value lies in its distinct mechanism of action, which provides a critical tool for studying pain pathways, neuropsychiatric disorders, and addiction without the typical mu-opioid side effects. This high-purity compound is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on developing novel central nervous system (CNS) therapeutics and exploring non-addictive analgesic alternatives.

Application

• Pharmacological Research: A key reference standard for studying kappa opioid receptor (KOR) signaling, function, and distribution in the CNS.
• Analgesic Development: Used as a lead compound or biochemical tool in the discovery and validation of novel, non-addictive pain relief medications.
• Neuropsychiatric Disorder Studies: Employed in preclinical research to investigate the role of the KOR system in depression, anxiety, and substance use disorders.
• Biochemical Assay Standard: Serves as a critical control and calibration standard in receptor binding assays, functional cell-based assays, and high-throughput screening (HTS) campaigns.
• Academic & Institutional Research: Provides a reliable research chemical for universities and institutes conducting fundamental neuroscience and medicinal chemistry studies.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profiles of kappa opioid agonists.

Basic Information

Product Name	Enadoline
CAS No.	107431-28-7
Molecular Formula	C24H28N2O3
Molecular Weight	392.49 g/mol
Synonyms	CI-977; Enadoline hydrochloride; (5R,6S,8S)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-4-benzofuranacetamide; U-62066E; Spiradoline mesylate (related salt); Kappa opioid receptor agonist CI-977
EINECS	Contact for details

Quality Control

Our Enadoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. For long-term storage, consider storing desiccated at -20°C. Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.