Description

(R)-6-Ethyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-10,11-Diol Hydrochloride CAS NO 18426-16-9 is a high-purity chiral intermediate and research chemical belonging to the tetrahydroisoquinoline class. This compound is of significant value for its role in advanced pharmaceutical synthesis and neuroscience research. It is primarily needed by R&D laboratories, pharmaceutical manufacturers, and fine chemical producers engaged in developing novel therapeutics, particularly for central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs).
• Neuroscience Research: Used as a reference standard or precursor in the study of dopaminergic and adrenergic receptor systems.
• Asymmetric Synthesis: Serves as a sophisticated starting material or intermediate in catalytic asymmetric reactions.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for new chemical entities (NCEs).
• Analytical Standard: Provides a high-purity standard for method development and validation in analytical laboratories (HPLC, LC-MS).
• Academic & Institutional Research: Utilized in universities and research institutes for medicinal chemistry and pharmacological studies.

Basic Information

Product Name	(R)-6-Ethyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-10,11-Diol Hydrochloride
CAS No.	18426-16-9
Molecular Formula	C19H21NO2·HCl
Molecular Weight	331.84 g/mol (Free base: 295.38 g/mol)
Synonyms	(R)-6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride; (R)-6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol HCl; (R)-6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol monohydrochloride; (R)-6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride salt; (R)-6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol HCl salt; (R)-6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol, hydrochloride; (R)-6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol, HCl; (R)-6-Ethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol, monohydrochloride
EINECS	Contact for details

Quality Control

Our (R)-6-Ethyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[De,G]Quinoline-10,11-Diol Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the stringent requirements of pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.