Description

Ebselen CAS NO 60940-34-3 is a potent organoselenium compound with significant antioxidant and anti-inflammatory properties, functioning as a glutathione peroxidase mimetic. Its primary value lies in its ability to modulate redox signaling pathways, making it a critical research tool and a promising candidate for therapeutic development. This compound is essential for pharmaceutical R&D, academic research in biochemistry and neurology, and preclinical studies targeting oxidative stress-related conditions.

Application

• Pharmaceutical Research & Development: Investigated as a neuroprotective agent and for therapeutic applications in stroke, hearing loss, and neurodegenerative diseases like Alzheimer's and Parkinson's.
• Biochemical Research: Used as a specific inhibitor and probe to study the role of reactive oxygen species (ROS), glutathione peroxidase activity, and thioredoxin reductase systems in cellular models.
• Anti-inflammatory Studies: Employed in preclinical research to investigate mechanisms for reducing inflammation, particularly by inhibiting enzymes like lipoxygenases and NO synthases.
• Antiviral Research: Studied for its potential activity against various viruses, including SARS-CoV-2, due to its interaction with key viral protease enzymes (e.g., Mpro).
• Chemical Biology Tool Compound: Serves as a reference standard and active agent in high-throughput screening and target validation assays.
• Material Science Research: Explored in niche applications for developing selenium-containing catalysts or functional materials.

Basic Information

Product Name	Ebselen
CAS No.	60940-34-3
Molecular Formula	C13H9NOSe
Molecular Weight	274.18 g/mol
Synonyms	2-Phenyl-1,2-benzisoselenazol-3(2H)-one; PZ 51; DR3305; SPI-1005; CCG-39161; Ebselene; Ebselan; L-PhSe-Phth
EINECS	Contact for details

Quality Control

Our Ebselen is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.