Description

trans-(1S 3R)-Acpd CAS NO 111900-32-4 is a high-purity, stereochemically defined chiral compound, also known as (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid, serving as a potent and selective group II metabotropic glutamate receptor (mGluR) agonist. This specificity makes it a critical pharmacological tool for neuroscience research, enabling the study of synaptic transmission, neuronal plasticity, and the pathophysiology of neurological disorders. It is essential for pharmaceutical R&D, academic institutions, and contract research organizations (CROs) focused on developing novel therapeutics for conditions like anxiety, pain, and Parkinson's disease.

Application

• Neuroscience Research: A key pharmacological tool for selectively activating group II metabotropic glutamate receptors (mGlu2/3) in vitro and in vivo studies.
• Drug Discovery & Development: Used as a reference standard and bioactive compound in high-throughput screening and lead optimization for CNS-targeted therapies.
• Mechanistic Studies: Investigating the role of glutamate signaling in synaptic plasticity, learning, memory, and neuronal excitability.
• Preclinical Model Validation: Employed in animal models to study the effects of mGluR modulation on behavior and disease progression.
• Biochemical Assay Development: Serves as a critical control and standard in developing and validating receptor binding and functional assays.
• Academic & Institutional Research: Fundamental reagent for university labs and research institutes exploring glutamatergic systems.

Basic Information

Product Name	trans-(1S 3R)-Acpd
CAS No.	111900-32-4
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	(1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid; (1S,3R)-ACPD; (1S,3R)-1-Amino-1,3-cyclopentanedicarboxylic acid; trans-(1S,3R)-ACPD; LY 354740 analogue; Group II mGluR Agonist; (+)-trans-ACPD
EINECS	Contact for details

Quality Control

Every batch of trans-(1S 3R)-Acpd is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and stereochemical integrity. Our quality commitment aligns with standards expected for advanced research chemicals. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, chiral purity, and impurity profiles via techniques such as HPLC, NMR, and optical rotation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.