Description

Bevasiranib is a highly specific, chemically synthesized small interfering RNA (siRNA) therapeutic agent designed to silence gene expression. This compound represents a significant advancement in the field of RNA interference (RNAi) for targeted therapeutic applications. It is primarily utilized in advanced pharmaceutical research and development, particularly for investigating novel treatments for ophthalmic conditions such as age-related macular degeneration (AMD).

Application

• Pharmaceutical R&D: Core material for the development and study of RNA interference-based therapeutics.
• Ophthalmic Drug Development: Key investigational compound for targeting vascular endothelial growth factor (VEGF) in conditions like wet age-related macular degeneration.
• Gene Silencing Studies: Used as a research tool in molecular biology and biochemistry to study specific gene knockdown mechanisms and efficacy.
• Preclinical & Clinical Trials: Serves as an active pharmaceutical ingredient (API) in formulation studies for preclinical and clinical-stage therapeutic programs.
• Biologics Manufacturing: Employed in process development and scale-up for the production of siRNA-based drugs under controlled GMP-like environments.

Basic Information

Product Name	Bevasiranib
CAS No.	959961-96-7
Molecular Formula	C412H492N159O250P39S39
Molecular Weight	~13600 g/mol (Exact mass varies with salt form)
Synonyms	Cand5; AGN 211745; Sirna-027; VEGF siRNA; Anti-VEGF siRNA; Bevasiranib sodium; Bevasiranib sodium salt; 5'-P-CCAUUCAGACGCUCAGUCCdT*dT-3', 3'-dT*dTGGUAAGUCUGCGAGUCAGG-5'
EINECS	Contact for details

Quality Control

Our Bevasiranib is manufactured and controlled under stringent quality systems to ensure it meets the exacting standards required for pharmaceutical research. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material suitable for research use under GMP-compliant conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Endotoxin (LAL)	< 10 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.