Description

5β-Dutasteride is a potent and selective inhibitor of both type 1 and type 2 5α-reductase isoenzymes, which are responsible for the conversion of testosterone to dihydrotestosterone (DHT). This compound is a key pharmaceutical intermediate of significant interest for the development of advanced therapeutic agents targeting androgen-dependent conditions. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of active pharmaceutical ingredients (APIs) for urological and dermatological treatments.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of Dutasteride and related 5α-reductase inhibitor APIs.
• Research & Development: Used in biochemical and pharmacological research to study the 5α-reductase enzyme pathway and its role in conditions like benign prostatic hyperplasia (BPH) and androgenetic alopecia.
• Reference Standard: Serves as a high-purity chemical reference standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Process Chemistry: Employed in route scouting and optimization for the scalable manufacturing of steroid-based therapeutics.
• Preclinical Studies: Utilized in the formulation of drug candidates for in vitro and in vivo efficacy and safety profiling.

Basic Information

Product Name	5β-Dutasteride
CAS No.	957229-52-6
Molecular Formula	C₂₇H₃₀F₆N₂O₂
Molecular Weight	528.53 g/mol
Synonyms	5β-Dutasteride; (5α,17β)-N-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide; GG745 5β-isomer; Dutasteride 5β-isomer; 4-aza-5β-androst-1-en-3-one-17β-carboxamide derivative
EINECS	Contact for details

Quality Control

Our 5β-Dutasteride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a Certificate of Analysis (COA) detailing specifications and test results, which is available upon request. Our quality commitment aligns with the standards expected for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.