Description

S-(-)-Tolterodine is the pharmacologically active enantiomer of tolterodine, a competitive muscarinic receptor antagonist. This high-purity chiral intermediate is critical for the synthesis of advanced pharmaceutical active ingredients with targeted therapeutic effects. It is primarily utilized by research institutions and pharmaceutical manufacturers developing and producing enantiomerically pure medications for the treatment of overactive bladder (OAB).

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of the active pharmaceutical ingredient (API) for antimuscarinic drugs.
• Enantioselective Synthesis: Used in research and production to create the therapeutically active S-enantiomer of tolterodine, ensuring higher potency and potentially reduced side effects.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Process Development: Employed in scaling up and optimizing manufacturing processes for enantiomerically pure pharmaceuticals.
• Clinical Research: Used in the formulation of drug products for preclinical and clinical trial materials.
• Generic Drug Manufacturing: Essential for companies producing generic versions of enantiomerically pure tolterodine-based medications.

Basic Information

Product Name	S-(-)-Tolterodine
CAS No.	124937-53-7
Molecular Formula	C22H31NO
Molecular Weight	325.49 g/mol
Synonyms	(R)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-methylphenol; (3R)-3-(2-Hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-amine; S-Tolterodine; (-)-Tolterodine; Levotolterodine; (R)-Tolterodine; Detrusitol (enantiomer); UNII-5T619TQR3R
EINECS	Contact for details

Quality Control

Our S-(-)-Tolterodine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity and chemical identity verification, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.