Description

Tolterodine CAS NO 124937-51-5 is a potent and selective muscarinic receptor antagonist, specifically developed for the treatment of overactive bladder (OAB) syndrome. Its primary value lies in its ability to reduce involuntary detrusor muscle contractions, thereby alleviating symptoms of urinary urgency, frequency, and incontinence. This active pharmaceutical ingredient (API) is essential for pharmaceutical manufacturers developing and producing finished dosage forms, such as extended-release capsules and tablets, for the global healthcare market.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for overactive bladder (OAB).
• Immediate-Release Formulations: Used in the production of standard tablets for rapid onset of therapeutic effect.
• Extended-Release Formulations: Critical for manufacturing controlled-release capsules that provide 24-hour efficacy from a single dose.
• Generic Drug Production: Serves as the key component for generic pharmaceutical companies following patent expirations.
• Clinical Trial Materials: Supplied as a reference standard or bulk ingredient for new drug formulation research and development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for toll manufacturing of finished drug products.

Basic Information

Product Name	Tolterodine
CAS No.	124937-51-5
Molecular Formula	C22H31NO
Molecular Weight	325.49 g/mol
Synonyms	(R)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-methylphenol; Tolterodine Base; (R)-Tolterodine; PNU-200583; Detrol (brand name); Detrustiol (brand name); Unidet (brand name); URITOL (brand name)
EINECS	Contact for details

Quality Control

Our Tolterodine is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications. Comprehensive testing includes identification, assay, impurity profiling (including related substances and residual solvents), and physical characterization. A Certificate of Analysis (COA) documenting compliance with relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Optical Rotation	+30.0° to +34.0° (c=1 in methanol)
Water Content (KF)	NMT 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.