Description

Distigmine Bromide is a quaternary ammonium compound that functions as a long-acting, reversible acetylcholinesterase inhibitor. This pharmacological profile makes it a critical agent for managing conditions associated with impaired neuromuscular transmission. It is primarily utilized in the pharmaceutical industry for the formulation of specialized medications. Distigmine Bromide CAS NO 15876-67-2 is essential for researchers and manufacturers focused on developing treatments for myasthenia gravis and postoperative urinary retention.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of prescription medications for neuromuscular disorders.
• Myasthenia Gravis Treatment: Formulated into tablets or injectables to improve muscle strength by enhancing cholinergic transmission.
• Postoperative and Neurogenic Bladder Dysfunction: Used in urological medicines to treat urinary retention by increasing bladder contractility.
• Research & Development: Serves as a key reference standard and biochemical tool in pharmacological studies of cholinesterase inhibition.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for similar cholinergic effects in animals.

Basic Information

Product Name	Distigmine Bromide
CAS No.	15876-67-2
Molecular Formula	C22H32Br2N4O4
Molecular Weight	576.33 g/mol
Synonyms	Hexamethylene-bis-[N-methyl-carbaminoyl-m-trimethyl-ammonium-phenolate] dibromide; Ubretid; BC 51; Hexamarium Bromide; 1,6-Hexanediylbis[methyl(3-[[(dimethylamino)carbonyl]oxy]phenyl)ammonium] Dibromide; Distigmini Bromidum
EINECS	Contact for details

Quality Control

Our Distigmine Bromide is manufactured under strict quality systems to ensure it meets the high-purity standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via validated methods such as HPLC. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to guarantee traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a cool, dry place. Recommended storage temperature is between 15°C and 25°C. Ensure the storage area is well-ventilated and away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.