Description

Ethyl 4-Fluoro-2-Methylbenzoylformate is a high-purity, synthetically valuable organic ester building block. This compound is a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique fluorinated aromatic structure is leveraged for its bioactivity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists working on novel active ingredients, including potential drug candidates and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine atom enhances lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers for advanced polymers with specific optical or electronic properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.
• Academic and Industrial R&D: A versatile reagent for methodological chemistry research and exploratory synthesis in fine chemical laboratories.

Basic Information

Product Name	Ethyl 4-Fluoro-2-Methylbenzoylformate
CAS No.	951888-61-2
Molecular Formula	C12H13FO3
Molecular Weight	224.23 g/mol
Synonyms	Ethyl (4-fluoro-2-methylphenyl)(oxo)acetate; 2-Methyl-4-fluorobenzoylformic Acid Ethyl Ester; Ethyl 4-Fluoro-2-methylbenzoylformate; Ethyl 2-(4-fluoro-2-methylbenzoyl)acetate; α-Oxo-4-fluoro-2-methylbenzeneacetic Acid Ethyl Ester; 951888-61-2; 4-Fluoro-2-methylbenzoylformic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 4-Fluoro-2-Methylbenzoylformate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to ISO 9001 standards, and we support development under ICH Q7 guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.