Description

2-(Trifluoromethyl)-1,4-Benzenedicarboxylic Acid is a high-purity aromatic dicarboxylic acid derivative featuring a strategically positioned trifluoromethyl group, which imparts unique electronic and steric properties. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block for the synthesis of complex organic molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials sectors seeking to incorporate fluorine motifs for enhanced bioactivity and material performance.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a backbone for creating sophisticated ligands and metal-organic frameworks (MOFs) used in catalysis and gas storage.
• Polymer Chemistry: Acts as a monomer for producing high-performance, fluorinated polyesters and polyamides with exceptional thermal and chemical resistance.
• Organic Electronic Materials: Employed in the research and development of electron-transport materials and semiconductors for OLEDs and photovoltaic cells.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2-(Trifluoromethyl)-1,4-Benzenedicarboxylic Acid
CAS No.	1483-47-2
Molecular Formula	C9H5F3O4
Molecular Weight	234.13 g/mol
Synonyms	2-(Trifluoromethyl)terephthalic Acid; Terephthalic Acid, 2-(Trifluoromethyl)-; 1,4-Benzenedicarboxylic Acid, 2-(Trifluoromethyl)-; 2-Trifluoromethylterephthalic Acid; 2-Carboxy-5-(trifluoromethyl)benzoic Acid; α,α,α-Trifluoro-5-carboxyisophthalic Acid; 2-TFTA
EINECS	Contact for details

Quality Control

Our production of 2-(Trifluoromethyl)-1,4-Benzenedicarboxylic Acid adheres to a stringent quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.