Description

2-(3,5-Bis(Trifluoromethyl)Phenyl)-2-Methyl Propanoic Acid is a high-value, multi-fluorinated aromatic carboxylic acid derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a sterically hindered α-methyl group and electron-deficient trifluoromethyl substituents, makes it indispensable for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery, catalyst design, and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the trifluoromethyl groups enhance lipophilicity and biological activity.
• Ligand & Catalyst Precursor: Serves as a precursor for sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic materials with specific electronic or surface properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Item	Detail
Product Name	2-(3,5-Bis(Trifluoromethyl)Phenyl)-2-Methyl Propanoic Acid
CAS No.	289686-70-0
Molecular Formula	C13H10F6O2
Molecular Weight	312.21 g/mol
Synonyms	2-Methyl-2-[3,5-bis(trifluoromethyl)phenyl]propanoic acid; α,α-Dimethyl-3,5-bis(trifluoromethyl)benzenepropanoic acid; 3,5-Bis(trifluoromethyl)-α,α-dimethylbenzenepropanoic acid; 2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropionic acid; 2-Methyl-2-(3,5-di(trifluoromethyl)phenyl)propanoic acid; 3,5-Di(trifluoromethyl)hydratropic acid; 2-(3,5-Di(trifluoromethyl)phenyl)-2-methylpropanoic acid
EINECS	Contact for details

Quality Control

Our production of 2-(3,5-Bis(Trifluoromethyl)Phenyl)-2-Methyl Propanoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. All materials undergo comprehensive analytical characterization using techniques including HPLC, GC, NMR, and MS. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting purity, identity, and impurity profiles. Our quality system is designed to support regulatory filings, and we can supply material compliant with ICH Q7 guidelines for active pharmaceutical ingredients (APIs).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.